Pharmaceutical Grade Glibenclamide Raw Powder For Hypoglycemic Drugs Cas 10238-21-8

High Quality Pharmaceutical Grade Glibenclamide Raw Powder For Hypoglycemic Drugs Cas 10238-21-8

Product Name: Glibenclamide
CAS: 10238-21-8
MF: C23H28ClN3O5S
MW: 494
EINECS: 233-570-6
Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts; Organics; Amino Acids & Derivatis; Isotope Labeled Compounds; API's; Potassium channel; Ion Channels; Isotope Labelled Compounds; API; GLYNASE; Diabetes Research
Mol File: 10238-21-8. mol

Hypoglycemic Agents Glibenclamide belongs to the second generation oral sulfonylurea drugs with the mechanism of action being similar as tolbutamide and the hypoglycemic effect being strongest among sulfonylurea drugs. Its intensity of action is about 200 to 250 times of that of Tolbutamide. It can selectively act on the pancreatic β-cells, promote secretion; can enhance the hypoglycemic effect of exogeg rate of 90% to 95% and half-life of 4 to 8 hours. It is mainly consumed by the liver metabolism with six metabolites. Two of them are knownous and strengthen the post-receptor effect of . It has fast oral absorption with high protein binding rate. It begins to take effect after 30 minutes with the effect being strongest at 1.5 hours and the duration of 16 to 24 hours. It has a distribution volume of 0.1L/kg, plasma protein bindinn as hydroxylated compounds with no hypoglycemic effect and is mainly excreted from the urine and a small amount is excreted by the stool. It is clinically mainly used for the treatment of mild to moderate non- dependent diabetes mellitus.

Application
1. Hypoglycemic drugs, for the treatment of mild, non insulin dependent diabetes mellitus
2. Glibenclamide and glibenclamide, glibenclamide, which belongs to the second generation oral sulfonylurea drugs, with the mechanism of toluene sulfonyl Ding Niao, its hypoglycemic effect was the strongest sulfonylurea, intensity for tolbutamide 200 ~ 250 times. Be selective effect on pancreatic beta cells, promote the secretion of insulin, can enhance the hypoglycemic effect of exogenous insulin, insulin receptor after strengthening effect.
3. Glibenclamide is one of the drugs currently used to treat type 2 diabetes, the most often used, because the utility function is fast and strong, so after the application has obvious effect, can effectively control blood sugar, high blood sugar, is applicable to other sulfonylurea hypoglycemic effect not beautiful person.



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