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Pharmaceutical Grade Furosemide Lasix 99% Purity For Diuretic Drug CAS 54 31 9
Lasix Basic Info
Other Name: Furosemide
Molecular Formula: C12H11ClN2O5S
CAS Registry Number: 54-31-9
Appearance: white powder
Molecular Weight: 330.74414
Lasix is not a hormone compound but a diuretic. Lasix belongs to the group of saluretics and to be exact is a loop diuretic. Lasix's effect consists of distinctly increased excretion of sodium, chloride, potassium, and water. A very important characteristic which must be absolutely monitored with loop diuretics is the reabsorbtion of potassium ions, sodium ions, and chloride ions. This causes a considerable disturbance of the electrolyte household.
Due to its intense effect on water excretion Lasix is used for treatment of edemas and high blood pressure. In bodybuilding some drug using Bodybuilders take Lasix shortly before a competition to excrete excessive, mostly subcutaneous, water so that they appear hard, defined, and ripped to the bone when in the limelight. The effect of tablets begins within an hour and continues for 3-4 hours. Depending on how much water is still in the athlete's body he must have more or less frequent access to a restroom. This can cause a considerable weight loss within a very short time.
For this reason, athletes often use Lasix to lose weight and to compete in a lower weight class. Athletes usually prefer the oral form of the compound. Bodybuilders occasionally use the injectable and intravenous version the morning of the competition since it becomes immediately effective when the athlete, due to a more or less strongly remaining water ifim, begins to panic.
This, however can also produce the opposite effect. That is, the muscles become small and flat; the athlete loses vascularity, and has no pump during warm-up when during a very short time too much water and minerals are lost. It is thus possible that some pro or top amateur shortly before the beginning of a competition as a last countermeasure is seen with a bag of glucose solution being injected intravenously so that the blood volume rises again. In order to compensate for the potassium loss many athletes take potassium chloride tablets. This, however, involves a certain risk since an overdose of potassium can cause cardiac arrest.
Usage And Synthesis:
Efficient diuretics Furosemide, is a class of efficient sulfonamide diuretics acting on the
medullary loop of the ascending branch of the medulla,it has a strong and short-term diuretic
effect,which can increase the excretion of water, sodium, chloride, potassium, calcium,
magnesium, phosphate and so on. It Mainly inhibits Na + and Cl-reabsorption in medullary and
cortex of the medullary loop ascending branch crude segment , it can promote the excretion of
sodium, chloride and potassium and affect the formation of renal medullary high osmotic
pressure,it can interfer the process of concentration and dilution of urine, and it can increase
urine output. This product can inhibit the activity of prostaglandin decomposition enzyme ,make
the content of prostaglandin E2 increase,it has effect on expansion of blood vessels, it also plays
a role in the proximal tubule, glomerular filtration,it can increase renal blood flow,and adjust renal
blood flow distribution,and reduce blood flow so that the cortex surface blood flow increases,it
promotes diuresis, its effect is fast and strong, it is used for other diuretics invalid cases.
Clinically it is used for the treatment of cardiac edema, renal edema, cirrhosis ascitic fluid,
peripheral edema caused by dysfunction or vascular disorders , and it may contribute to an upper
urinary tract stones excretion. Administration intravenously can treat brain edema, it also can
accelerate the excretion of toxic substances in cerebral edema in poisoning . Note that when the
diuretic furosemide is used, since the excretion of urine Cl-, Na +, K +, H + is increasing, while
the excretion of HCO3-is not increasing, long-term repeated drug use or large quantities of drugs
can cause low salt syndrome, low chlorine and low potassium alkalosis.
In recent years, researchers find that inhalation of furosemide can have a significant effect on
asthma, it is like cromolyn sodium, which through inhibition of allergic mediator release, it can
inhibit the release of the neurotransmitter acetylcholine and substance P, which may be related to
inhibiting chloride ions into the cell membranes of respiratory tract. Clinically,it is used in
exercise-induced asthma, immediate and delayed type antigen-induced asthma.
Chemical properties white or white alike crystalline powder. 206 ℃ melting point. Dissolved in
acetone, methanol, dimethyl formamide, slightly soluble in ethanol, insoluble in water. Odorless,
Uses The diuretic effect of this product is a strong and short,it is a potent diuretic for the treatment
of edema caused by heart, liver, kidney and other diseases, in particular, the base cases which
other diuretics are invalid to;it can be used to treat acute pulmonary edema, brain edema , acute
renal failure and high blood pressure and other diseases; in combination with fluid infusion, the
product can promote poison excretion. Rat oral LD50 is 2600-2820mg/kg.
production method 2,4-dichlorobenzoic acid (see 12740) by sulfochlorination,ammoniation,
acidification ,dichloro-5-sulfamoyl-benzoic acid is obtained. Then after condensation with the
chaff amine , furosemide is produced.
Category Toxic substances
Toxicity grading Middle toxic
Acute toxicity Oral-rat LD50: 2600 mg/kg; Oral-Mouse LD50: 2200 mg/kg.
Flammability and hazard characteristics Combustible; fire decomposition produces toxic
nitrogen oxides; sulfur oxides and chlorides smoke.
Storage Characteristics Ventilated, low-temperature ,dry storeroom.
Extinguishing agent Water, carbon dioxide, dry powder,sandy soil.
Chemical Properties white to light yellow crystal powde
Uses diuretic, antihypertensive
Uses Furosemide inhibits ion co-transport in the kidney. Furosemide is used as a diuretic.
Uses This compound belongs to the aminobenzenesulfonamides. These are organic compounds
containing a benzenesulfonamide moiety with an amine group attached to the benzene ring.
Uses An inhibitor of NKCC and a GABAA receptor antagonist.
General Description Odorless white to slightly yellow crystalline powder. A diuretic drug. Almost
Air & Water Reactions Light sensitive. Air sensitive. Slightly soluble in water.
Reactivity Profile Furosemide may undergo hydrolysis at sufficiently low pH. The pH of aqueous
solutions should be maintained in the basic range to prevent hydrolysis. Alcohol has been shown
to improve the stability of Furosemide. Incompatible with strong oxidizing agents .
Fire Hazard Flash point data for Furosemide are not available; however, Furosemide is probably
Biological Activity Loop diuretic that inhibits the Na + /2Cl - /K + (NKCC) cotransporter. Also acts
as a non-competitive antagonist at GABA A receptors with ~ 100-fold greater selectivity for α 6-
containing receptors than α 1-containing receptors.
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