Gamma Butyrolactone Chemical Raw Materials 1 4 Butyrolactone GBL CAS 96-48-0

Gamma Butyrolactone Chemical Raw Materials 1 4 Butyrolactone GBL CAS 96-48-0

Gamma Butyrolactone Quick Detail:
Product name: GBL Gamma Butyrolactone
No. 96-48-0
Chemical Name: gamma-Butyrolactone
Synonyms: GBL;BLO;6480;BLON;c-1070;GBL-EL;gamma-BL;CadionGr;Butanolid;FEMA 3291
Molecular Formula: C4H6O2
Formula Weight: 86.09
Chemical Properties:colourless oily liquid
General Description:Clear colorless oily liquid with a pleasant odor.
Air & Water Reactions:Hygroscopic,Soluble in water.
Packing: According to the request.
Certification:SGS;ISO9000
Usage :pharmaceutical raw materials, the hormone
Assay: 99%
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Description

GBL is a lactone. It is hydrolyzed under basic conditions, for example in a sodium hydroxide solution into sodium gamma - hydroxybutyrate, the sodium salt of gamma - hydroxybutyric acid. Under acidic conditions it forms an equilibrium mixture of both compounds. These compounds then may go on to form a polymer. When treated with a non - nucleophilic base, like lithium diisopropylamide, GBL can become an alpha - carbon nucleophile. The related compound caprolactone can be used to make a polyester in this manner.

GBL is not active in its own right; its mechanism of action stems from its identity as a prodrug of GHB. The hypnotic effect of GHB is enhanced by combination with alcohol. A 2003 rat study showed that GBL in combination with ethanol showed a potentiated hypnotic effect, as the sleep-timing measure was longer than both of the individual components combined

GBL is rapidly converted into GHB by paraoxonase ( lactonase ) enzymes, found in the blood. Animals which lack these enzymes exhibit no effect from GBL. GBL is more lipophilic ( fat soluble ) than GHB, and so is absorbed faster and has higher bioavailability. Because of these pharmacokinetic differences, GBL tends to be more potent and faster - acting than GHB, but has a shorter duration; whereas the related compound 1,4- butanediol ( 1,4- B ) tends to be slightly less potent, slower to take effect but longer - acting than GHB.

Gamma Butyrolactone is an important chemical raw material and intermediate for medicine, and also the intermediate of the synthesize N-methyl pyrrolidone, α -pyrrolidone, polyvinyl pyrrolidone, α -acetyl-γ -butyrolactone, methionine and the butyric acid compounds. This product features a strong solubility, and is a good solvent for polyacrylonitrile, epoxy resin, polyvinyl butyral, polyvinyl chloride and its copolymers, and cellulose polymers. In medical industry, it is mainly used in synthesizing cyclopropylamine, etc

gamma-Butyrolactone(GBL) introduction:

Gamma-Butyrolactone (γ-butyrolactone or GBL) is a hygroscopic colorless liquid with a weak characteristic odor which is soluble in water. GBL is a common solvent and reagent in chemistry as well as being used as a flavouring, as a cleaning solvent, as a superglue remover, and as a solvent in some wet aluminium electrolytic capacitors. In humans it acts as a prodrug for GHB, and it is used as a recreational intoxicant with effects similar to alcohol.

GBL is a lactone. It is hydrolyzed under basic conditions, for example in a sodium hydroxide solution into sodium gamma-hydroxybutyrate, the sodium salt of gamma-hydroxybutyric acid. Under acidic conditions it forms an equilibrium mixture of both compounds. These compounds then may go on to form a polymer. When treated with a non-nucleophilic base, like lithium diisopropylamide, GBL can become an alpha-carbon nucleophile. The related compound caprolactone can be used to make a polyester in this manner.

GBL is rapidly converted into GHB by paraoxonase (lactonase) enzymes, found in the blood.[7][8] Animals which lack these enzymes exhibit no effect from GBL.[7] GBL is more lipophilic (fat soluble) than GHB, and so is absorbed faster and has higher bioavailability. Because of these pharmacokinetic differences, GBL tends to be more potent and faster-acting than GHB, but has a shorter duration; whereas the related compound 1,4-butanediol (1,4-B) tends to be slightly less potent, slower to take effect but longer-acting than GHB.

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