Enhancing Memory Choline Glycerophosphate Alpha GPC Choline Alfoscerate 28319 77 9
Product Name:Choline Glycerophosphate
Alias:L-Alpha glycerylphosphorylcholine,Choline alfoscerate,alpha-GPC
L-Alpha glycerylphosphorylcholine (alpha-GPC, choline alfoscerate) is a natural choline compound found in the brain. It is also a parasympathomimetic acetylcholine precursor which may have potential for the treatment of Alzheimer's disease and other dementias.
Alpha-glycerophosphocholine (Alpha-GPC or α-GPC) is a cholinergic compound that is used for its cognitive-promoting properties, and to enhance power output in athletes. It appears to also support cellular membranes, and may aid in preventing cognitive decline.
Alpha-GPC (Alpha-glycerophosphocholine or sometimes just glycerophosphocholine) is a Choline-containing supplement that, although found in a variety of food products that are also rich in choline, appears to be pharmacologically active at higher doses.
Alpha-GPC is mostly marketed due to it conferring dietary choline to the body following oral ingestion, and being the most efficient choline prodrug at doing so (able to influence both systemic and brain concentrations of choline). Due to the provision of the other half of the alpha-GPC molecule (glycerophosphate), alpha-GPC also appears to support the structure of cellular membranes, which is not a common mechanism attributed to choline prodrugs (only CDP-choline is associated with lipid membranes in this sense).
Oral supplementation of alpha-GPC is of interest for nootropic purposes, as it appears to have cognitive-enhancing properties (no human evidence exists to support this in otherwise-healthy youth, but it does have support in rodents) and attenuate the rate of cognitive decline in the elderly. In regards to reducing the rate of cognitive decline, alpha-GPC at high doses (1,200 mg) does appear to be somewhat effective in mild to moderate Alzheimer's disease and works nicely with the standard therapy (acetylcholinesterase inhibitors).
Athletes are at times interested in alpha-GPC due to its ability to enhance growth homone production (of which only acute spikes have been reported so far, so it may fall to the same problems that Arginine has on growth homone) and to enhance power output, which has a lone pilot study in support of 600 mg alpha-GPC prior to exercise. Although ergogenic properties of alpha-GPC cannot be ruled out and look promising, it requires more evidence.
Neutral odor, very highly hygroscopic.
||Conforms to the standard
|Solubility(H2O, 10% w/v)
|Bulk Density (Untapped)
Dry and light protected storage;
Stable under normal usage.
|Color of solution
|Related Substances (HPLC)
|Glycerophosric acid: <0.2%
1. Alpha GPC increase a chemical in the brain called acetylcholine. This brain chemical is important for memory and learning functions.
2. alpha-GPC is a prescription medication for the treatment of Alzheimer s disease. It is available in two forms; one is taken by mouth, and the other is given as a shot. In the United States alpha-GPC is only available as a dietary supplement, mostly in products promoted to improve memory.Other uses for alpha-GPC include treatment of various kinds of dementia, stroke, and “mini stroke” (transient ischemic attack, TIA). Alpha-GPC is also used for improving memory, thinking skills, and learning.
3.Alpha GPC rapidly delivers choline to the brain across the blood–brain barrier and is a biosynthetic precursor of the acetylcholine neurotransmitter. Alpha GPC is derived from highly purified soy lecithin.
4. Alpha GPC or GPC has been documented extensively by published studies in both animals and humans to contribute to at least five signt human health functions.
Alpha GPC Growth Hormone
Research supports choline alfoscerate' s ability to support healthy brain function and the release of somatotrophin (hGH).
Another study has reported that 600mg Alpha-GPC taken 45 minutes prior to physical exercise is able to augment the exercise-induced growth hormone spike from 5.0+/-4.8ng/mL in placebo to 8.4+/-2.1 ng/mL with supplementation. The increase appeared to be significantly more than placebo when measured immediately and up to 15 minutes after exercise cessation, normalizing at 60 minutes.
One study using Alpha-GPC at 1,000mg has reported that, in otherwise healthy men, an increase in plasma biomarker of lipolysis (the ketone bodies acetoacetate and 3-hydroxyacetate, as well as free fatty acids) was reported to occur 120 minutes after supplement ingestion
supplemental of Alpha-GPC given 600mg Alpha-GPC prior to a power test (bench throws) reported a 14% power output improvement relative to placebo when taken 45 minutes prior to activity.
A standard dosage of alpha-GPC is 300-600 mg, according to the most common label doses. This dose is in accordance with the study using alpha-GPC to enhance power output (600 mg) and the two studies noting an increase in growth hormone secretion, and is likely a good dose to take for athletes.
For the usage of alpha-GPC in attenuating symptoms of cognitive decline, almost all studies use a dosage of 1,200 mg daily, divided into three doses of 400 mg. It is unsure how lower doses would benefit cognition, but the 1,200 mg appears to be consistently associated with benefit.