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Anti Aging Melatonine Raw Powder Pharmaceutical Intermediates CAS 73-31-4
Melatonin, chemically N-acetyl-5-methoxytryptamine,is a substance found in animals, plants, fungi and bacteria. In animals it is a hormone that anticipates the daily onset of darkness;however in other organisms it may have different functions. Likewise, the synthesis of melatonin in animals differs from that in other organisms. In animals, melatonin is involved in the entrainment (synchronization) of the circadian rhythms of physiological functions including sleep timing, blood pressure regulation, seasonal reproduction and many others.Many of melatonin's biological effects in animals are produced through activation of melatonin receptors,while others aRe due to its role as a pervasive and powerful antioxidant,with a particular role in the protection of nuclear and mitochondrial DNA.
Melatonine is a hormone, secreted by the pineal gland in the brain that helps regulate other hormones and maintains the body's circadian rhythm. The circadian rhythm is an internal 24-hour time-keeping system that plays a critical role in determining when we fall asleep and when we wake up. Darkness stimulates the production of melatonin while light suppresses its activity. Exposure to excessive light in the evening or too little light during the day can disrupt the body's normal melatonin cycles. For example, jet lag, shift work, and poor vision can disrupt melatonin cycles. Melatonin is a hormone found naturally in the body. Melatonin used as medicine is usually made synthetically in a laboratory. It is most commonly available in pill form, but melatonin is also available in forms that can be placed in the cheek or under the tongue. This allows the melatonin to be absorbed directly into the body. People use melatonin to adjust the body's internal clock. It is used for jet lag, for adjusting sleep-wake cycles in people whose daily work schedule changes (shift-work disorder), and for helping blind people establish a day and night cycle.
Melatonin is also used for the inability to fall asleep (insomnia); delayed sleep phase syndrome (DSPS); rapid eye movement sleep behavior disorder (RBD); insomnia associated with attention deficit-hyperactivity disorder (ADHD); insomnia due to certain high blood pressure medications called beta-blockers; and sleep problems in children with developmental disorders including autism, cerebral palsy, and intellectual disabilities. It is also used as a sleep aid after discontinuing the use of benzodiazepine drugs and to reduce the side effects of stopping smoking. The hormone can be used as a sleep aid and in the treatment of some sleep disorders. It can be taken orally in liquid form as well as capsules or tablets in immediate- or prolonged-release form. It is also available in a form to be used sublingually, and as transdermal patches. Melatonin is sold over-the-counter in the U.S. and Canada. In other countries it may require a prescription or it may be unavailable
People use melatonin to adjust the body's internal clock. It is used for jet lag, for adjusting sleep-wake cycles in people whose daily work schedule changes (shift-work disorder), and for helping blind people establish a day and night cycle. Melatonin is also used for the inability to fall asleep (insomnia); delayed sleep phase syndrome (DSPS); insomnia associated with attention deficit-hyperactivity disorder (ADHD); insomnia due to certain high blood pressure medications called beta-blockers; and sleep problems in children with developmental disorders including autism, cerebral palsy, and intellectual disabilities. It is also used as a sleep aid after discontinuing the use of benzodiazepine drugs and to reduce the side effects of stopping smoking.
Melatonine supplements are Mainly used for treating jet lag or sleep problems (insomnia). Some use melatonin for chronic fatigue syndrome (CFS), fibromyalgia, migraine and other headaches, bone osteoporosis, as an anti-aging agent, for menopause, and for birth control. Melatonin also helps control the timing and release of female reproductive hormones. It helps determine when menstruation begins, the frequency and duration of menstrual cycles, and when menstruation ends (menopause).
Melatonine as an anabolic hormone drugs, can promote protein synthesis and inhibiting protein dysplasia, and can lower blood cholesterol, reduce calcium phosphorus excretion and reduce bone marrow suppression, promoting development, promote tissue freshmen and granulation. Caused by long-term use of adrenal cortical hormone have prevention and protection against the adrenal cortex hypofunction.
|Product Name||Melatonin||CAS: 73-31-4|
|Assay( HPLC )||99.0-102%||99.56%|
|Description||White or almost white, crystalline powder or colorless crystals.||White crystalline powder|
|Identification||IR & UV||Confirm|
|Melting point||116-120 °C||117.2-117.8 °C|
|Loss on drying||< 0.5%||0.18%|
|Residue on ignition||< 0.1%||0.07%|
|Related substances||< 0.1%||confirm|
|Heavy metal||< 10 ppm||0.8 ppm|
|total viable count||< 3000cfu/g||confirm|
|yeast and moulds||< 300cfg/g||confirm|
1) Melatonin can effectively improve sleep quality
2) Melatonin can improve the functional status of the whole body
3) Melatonin can improve human immunity, prevent depression, Alzheimer's syndrome, cataracts, for the treatment of glaucoma also had a marked effect.
4) Melatonin can increase the body's immune system, auxiliary cancer, enhance physical fitness.
5) Melatonin has strong antioxidant effects
6)Improve sleep dosage (0.1 ~ 0.3 mg), and can shorten the awakening time and sleeping time before sleep, improve sleep quality, sleep wake up significantly reduced, short shallow sleep stage, extending deep sleep stage, in the morning wake up threshold value.Has the strong adjust time difference function.
How Does Melatonin Work?
Natural melatonin is a highly lipid soluble hormone produced in the pineal gland in the brain. It is synthesized from the amino acid tryptophan and then released into the blood and cerebrospinal fluid, crossing the blood-brain barrier. It sends messages to the melatonin receptor agonist in the brain and other areas of the body to help control the sleep and wake cycles.
Does melatonin help you sleep? When taken as supplement, the function of melatonin is to mimic the effects of the natural hormone. Drowsiness generally occurs within 30 minutes after taking melatonin. However, taking melatonin right before bed may not be the best strategy for all sleep disorders. Ask your doctor about the best method of dosing melatonin. Melatonin does not work for everyone.
Before Taking This Medicine
Do not use melatonin if you are allergic to it.
Before using melatonin, talk to your healthcare provider. You may not be able to use this medication if you have certain medical conditions, such as:
It is not known whether melatonin will harm an unborn baby. Do not use this product without medical advice if you are pregnant.
High doses of this medicine may affect ovulation, making it difficult for you to get pregnant.
It is not known whether melatonin passes into breast milk or if it could harm a nursing baby. Do not use this product without medical advice if you are breast-feeding a baby.
Melatonin is considered an effective treatment for jet lag and can aid sleep during times when you would not normally be awake.
Effective starting doses for jet lag range from 0.3 to 0.5 mg. One milligram tablets can be cut in half to achieve a 0.5 mg dose if smaller doses are not available for purchase. Lower doses may work for some people, while others may need a higher dose, up to 3 to 5 mg. However, higher doses may be associated with more side effects such as headache, next day grogginess, or vivid dreams.
Always start with the lowest melatonin dose. According to a Cochrane review, doses over 5 mg appear to be no more effective than lower doses. It is important to note that much higher doses are available for sale in the U.S., but these doses may result in excessively high levels of physiologic melatonin.
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