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steroid based hormones,
anabolic steroid hormones
PT 141 Acetate Peptide Steroid Hormones Bremelanotide Powder CAS 32780-32-8
Synonyms: Bremelanotide, PT-141 Acetate
CAS : 189691-06-3
Molecular Formula: C50H68N14O10
Molecular Mass: 1025.2 Da (g/mol)
Amino Acid Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH
PT-141 has a peptide purity level that exceeds 99.0% as determined by HPLC and MS. This peptide was synthesized with no additives and is supplied as a white lyophilized (freeze-dried) powder.
PT-141 or Bremelanotide is the generic term for a research peptide being studied for its possible use in helping to improve sexual dysfunction in both men (erectile dysfunction or impotence) and women (sexual arousal disorder). PT-141 was developed from the tanning peptide Melanotan 2, which is a synthetically produced variant of a peptide hormone naturally produced in the body that stimulates melanogenesis that is known as alpha-Melanocyte stimulating hormone. MSH, activates certain melanocortin receptors in the process of exerting its effects. Indeed, MSH also exerts potent influence over lipid metabolism, appetite, and sexual libido. Resultantly, PT-141 has been shown in studies to exhibit libido-enhancing effects by activating the melanocortin receptors MC1R and MC4R, but not skin tanning. Melanotan 1 and Melanotan 2 have been researched for their use in protecting against the harmful effects of ultraviolet radiation from sunlight due to their melanogenesis-stimulating properties.
As a lifestyle peptide, the 10mg product is a lot to consume and may offer up to 20 doses when dosing light. The PT-141 peptide reconstituted with bacteriostatic water remains potent in the fridge for months.
PT-141 / Bremelanotide is a synthetic heptapeptide analogue of the naturally occuring α-MSH that is currently being studied for its numerous theoretical therapeutic applications. Alpha-MSH has potent influence over lipid metabolism, appetite, and sexual libido.
PT-141/ Bremelanotide is a metabolite of its predecessor MT-2, has the amino acid sequence Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH and a molecular weight of 1025.2 Dalton.
In initial testing, MT-2 did induce melanogenesis, but caused sexual arousal and spontaneous erections as unexpected side effects in nine out of the ten original male volunteer test subjects Alpha-MSH activates certain melanocortin receptors in the process of exerting its effects.
PT-141 is a potential remedy for the treatment of sexual dysfunction; specifically, male erectile dysfunction. Studies have shown that PT-141 does not act on the vascular system like former compounds, but allegedly works by activating melanocortin receptors in the brain, therefore helping increase ones sexual stimulation. PT-141 is a melanocortin based peptide that has shown effectiveness in clinical studies on both male and female rats. Male rats have shown erectile response with doses as low as 1-2 mgs whereas most female rats have shown positive results with higher doses around 2-3 mgs. While the dosage requirements tend to be higher for female rats, the observable results in female rats tend to be stronger.
How Does PT-141 Work?
PT-141 increases your sexual desire by activating the brain of the melanocortin 4 receptor, which normally regulates the metabolism, male erectile function and sexual behaviour. Its operating mechanism typically involves an action in your central nervous system (CNS) instead of directly on the cardiovascular system.
Why Use Bremelanotide (PT-141)
Initially, Bremelanotide was considered as a UV filled tanning (sunless tanning) agent, and it had its origins from a peptide hormone called Melanotan II, a melanocortin peptide hormone that occurs naturally and used to produce melanogenesis (which is the production of the pigment that is found in your skin, hair and eyes).
Usage and Dosage
Subcutaneous injection is administered on to fatty tissues under the skin. the fatty layer is situated immediately beneath the skin and contains few blood vessels.
Size of vile: 10mg
Frequency of use: taken within 2-4 hours before engaging in sexual intercourse.
Where to inject: The abdomen surrounding skin for injecting the peptide
Injection Dosage per time: 0.75, 1.25 and 1.75 mg.
Suggested Water to mix: Bacteriostatic water or sterile water
How much water to add: mix with 2ml of water
How to Mix the water and peptide together: 2ml(cc) bacteriostatic water per 10mg PT-141
Storage: Lyophilized PT-141 is stable at room temperature for 90 days,however it should be stored in a freezer below -8C for any extended period of time. After reconstituting PT-141 should be refrigerated at temperatures not to exceed 36 F.
PT141 Bremelanotide (Acetate) PT-141 COA
|Product Name||CJC 1295 DAC||Other Names||Pegylated Mechano Growth Factor|
|Appearance||White powder||Single Impurity (HPLC)||1.0%max|
|M.F.||Amino Acid Composition||±10% of theoretical|
|Peptide Content (N%)||≥80.0%||Water Content(Karl Fischer)||≤6.0%|
|Acetate Content (HPLC)||≤15.0%||MS(ESI)||Consistent|
|Mass Balance||95.0~105.0%||Specific Rotation (20/D)||-65.0~-75.0°(c=0.5 1%HAc)|
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l your doctor immediately. You may need to increase your dose of tablets or liquid temporarily or start taking them again.
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