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| Product Name: | Tetracaine Hydrochloride | Cas: | 136-47-0 |
|---|---|---|---|
| Purity: | 99% | Appearance: | White Powder |
| Usage: | Local Anesthetic | ||
| High Light: | lidocaine hcl powder,procaine hcl powder |
||
Local Anesthesia Materials Tetracaine Hydrochloride Raw Powder CAS 136 47 0
Basic Details:
Product Name: Tetracaine hydrochloride
Synonyms: INTERCAIN HYDROCHLORIDE
CAS: 136-47-0
MF: C15H25ClN2O2
MW: 300.82
EINECS: 205-248-5
mp: 149°C
storage temp: Refrigerator
Appearance: White Solid
Tetracaine Hydrochloride COA
| APPEARANCE | FINE, WHITE, CRYSTALLINE, ODORLESS POWDER |
| IDENTIFICATION | A B C IN PASS |
| RESIDUAL SOLVENTS | ETHANOL (III)<0.5% |
| SOLUBILITY |
VERY SOLUBLE IN WATER, SOLUBLE IN ALCOHOL; INSOLUBLE IN ETHER AND BENZENE |
| USP REFERENCE STANDARDS | USP TETRACAINE HYDROCHLORIDE RS USP ENDOTOXIN RS |
| CHROMATOGRAPHIC PURITY | CONFORMS |
| OTHER REQUIREMENTS | CONFORMS |
| ACIDITY | CONFORM |
| WATER | ¡Ü2.0% |
| RESIDUE ON IGNITION | ¡Ü0.10% |
| ASSAY | 98.5-101.0% |
Description:
1. In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.
2. Tetracaine is the T in Tac, a mixture of 5 to 12 per cent tetracaine, 5M(per myriad), a half per mille (0.5‰), or .05 per cent (1 part in 2000) , and 4 or 10 per cent hydrochloride used in ear, nose & throat surgery and in the emergemcy department where numbing of the surface is needed rapidly, especially when children have been injured in the eye, ear, or other sensitive locations.
3. Tetracaine is synthesized from 4-butylaminobenzoic acid. The ethyl ester is formed through an acid-catalyzed esterification reaction. Base-catalyzed transesterification is achieved by boiling the ethyl ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a small amount of sodium ethoxide.
Application:
Tetracaine is a potent local anesthetic of the ester group.
It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.
In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores.
Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.
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