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|Grade:||Pharmaceutical Grade||Usage:||Gastric Ulcer Treatment|
raw hormone powders,
anabolic powder supplements
High Purity 99% Misoprostol Raw Steroids Powder For Gastric ulcer Treatment Cas 59122-46-2
Product Name: Misoprostol
HS Code: 3001200010
Appearance: White Solid
Package 1kg/aluminium foil bag
Biological Activity:Cytoprotective prostaglandin E 1 analog that displays agonist activity at EP receptors. K i values are 120, 250, 67 and 67 nM at cloned mouse EP 1 , EP 2 , EP 3 and EP 4 receptors respectively. Prevents NSAID-induced gastric ulceration.
Application: Misoprostol is a synthetic analogue of E1, its role is to make the woman's uterus muscles and tissues become loose, in order to achieve increased cervix dilation purposes, safe way to terminate pregnancy.
Misoprostol is approved for use in the prevention of NSAID-induced gastric ulcers. It acts upon gastric parietal cells, inhibiting the secretion of gastric acid by G-protein coupled receptor-mediated inhibition of adenylate cyclase, which leads to decreased intracellular cyclic AMP levels and decreased proton pump activity at the apical surface of the parietal cell. Because other classes of drugs, especially H2-receptor antagonists and proton pump inhibitors, are more effective for the treatment of acute peptic ulcers, misoprostol is only indicated for use by people who are both taking NSAIDs and are at high risk for NSAID-induced ulcers, including the elderly and people with ulcer complications. Misoprostol is sometimes coprescribed with NSAIDs to prevent their common adverse effect of gastric ulceration (e.g. with diclofenac in Arthrotec).
Misoprostol has other protective actions, but is only clinically effective at doses high enough to reduce gastric acid secretion. For instance, at lower doses, misoprostol may stimulate increased secretion of the protective mucus that lines the gastrointestinal tract and increase mucosal blood flow, thereby increasing mucosal integrity. However, these effects are not pronounced enough to warrant prescription of misoprostol at doses lower than those needed to achieve gastric acid suppression.
However, even in the treatment of NSAID-induced ulcers, omeprazole proved to be at least as effective as misoprostol,but was significantly better tolerated, so misoprostol should not be considered a first-line treatment. Misoprostol-induced diarrhea and the need for multiple daily doses (typically four) are the main issues impairing compliance with therapy.
|Appearance||White crystalline powder|
|Chromatographic purity||Any individual impurity not more than 1.0% Total impurities ≤2.0%||0.27% 0.7%|
|Loss on drying||Not more than 0.5%||0.1%|
|Residue on ignition||Not more than 0.2%||0.1%|
|Residual solvents||Methanol≤3000ppm||350ppm Not detect out|
|Assay||Between 97.0% and 102.0%||99.2%|
|Micronixation||90% not more than 10 microns||90% not more than 10 aicrons|
High quality with competitive price:
1) Standard: Enterprise Standard
2) All Purity:>=99%
3) We are manufacturer and can provide high quality products with factory price.
Fast and safe delivery:
1) Parcel can be sent out in 24 hours after payment. Tracking number available
2) Secure and discreet shipment. Various transportation methods for your choice.
3) Customs pass rate: >=99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring.
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