CAS 57-63-6 Female Anabolic Steroids Ethinylestradiol For Contraceptive Medicinal
CAS: NO. 57-63-6
Molecular Formula: C20H24O2
Molecular Weight: 296.41
Appearance: White powder
Melting Point: 180~186
Loss on drying: ≤ 1.0%
Ethinylestradiol is a man-made form of the naturally occurring female hormone called oestrogen. It is prescribed to treat period (menstrual) problems, and also to help ease menopausal symptoms. It is usually prescribed alongside another female hormone called a progestogen.
Ethinyl estradiol also sometimes written as ethinylestradiol, ethynyl estradiol, or ethinyl Stradiol, is a derivative of 17β -estradiol (E2), the major endogenous estrogen in humans. EE is an orally bioactive estrogen used in many formulations of combined oral contraceptive pills. It is one of the most commonly used medications for this purpose.
Estinyl was a preparation of EE alone that was used for the management of menopausal symptoms and female hypogonadism.
EE is released into the environment as a xenoestrogen from the urine and feces of people who take it as a medication.
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Ethinyl Estradiol is absorbed in the small intestine and reaches a serum peak about 2 hours later. It undergoes extensive metabolism in the liver involving the cytochrome P450 3A4 isoenzyme.
Ethinyl Estradiol and its metabolites are excreted with the bile. Due to the effect of entero hepatic circulation a second peak is seen several hours later. Individually, wide variations exist in the overall absorption process, and can be further modified by drugs that affect the enterohepatic circulation or liver enzymes.
In circulation Ethinyl Estradiol is almost fully bound to plasma albumin. It is metabolized by hydroxylation of the aromatic ring and excreted in both feces and urine, in part as glucuronide and sulfate conjugate.
Ethinyl Estradiol is hormonally effective by activating the estrogen receptor and thus is an estrogen. It finds its most common use in the estrogen-progestin combination preparations of oral contraceptives. Over time, formulations have decreased the Ethinyl Estradiol dose from as high as 100 μg to as low as 10 μg in.
This combination hormone medication is used to prevent pregnancy. It contains 2 hormones: a progestin and an estrogen. It works mainly by preventing the release of an egg (ovulation) during your menstrual cycle. It also makes vaginal fluid thicker to help prevent sperm from reaching an egg (fertilization) and changes the lining of the uterus (womb) to prevent attachment of a fertilized egg. If a fertilized egg does not attach to the uterus, it passes out of the body.
Besides preventing pregnancy, birth control pills may make your periods more regular, decrease blood loss and painful periods, decrease your risk of ovarian cysts, and also treat acne.
1. For women with menopausal syndrome: 0.02～0.05mg a time, 1~3 times a day.
2. For functional uterine bleeding, uterine hypoplasia, prostate cancer, amenorrhea, amenorrhea and other diseases: 0.02 to 0.05mg a time, 2~3 times a day.
3. Gonadal dysgenesis: 0.02 to 0.05mg a time, one time at night, continue for 3 weeks, in third weeks with progesterone for artificial cycle treatment, available for 1~3 cycles.
4. Perimenopausal syndrome: 0.025 to 0.05mg per day, continue for 21 days, interval 7 days later, women who have the uterus, take progesterone 10~14 times after the cycle
5. Common symptoms include nausea, vomiting, headache, and breast tenderness.
||White to creamy white, odorless, crystalline powder.
||white crystalline powder
||Insoluble in water; soluble in alcohol, in chloroform, in ether, in vegetable oils, and in solutions of fixed alkali hydroxides.
|Specific optical rotation
|Loss on drying
||97.0~102.0% (on the dried basis)
||The product complies with specification in USP34
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