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|Product Name:||Oxytocin Acetate||Cas:||50-56-6|
steroid based hormones,
human growth peptides
CAS 50-56-6 Peptide Steroid Hormones Oxytocin Acetate For Hasten Parturition
Product Name:Oxytocin Acetate
Cas No.: 50-56-6
Product Categories:Amino Acid Derivatives;Organics
Purity (HPLC): 99.0%min.
Appearance: White powder
Molecular Formula: C43H66N12O12S2
Molecular Weight: 1007.2
Grade : Pharmaceutical Grade
Storage: Closed, below 2 ~ 8ºC preservation
Manufacturer : holybiological
Usage : For induction of labor, postpartum oxytocin, and abortion due to uterine atony or retraction caused by the bad uterus bleeding; understand the placental function reserve (oxytocin challenge test); nasal drops can promote milk.
Oxytocin (Oxt) is a mammalian neurohypophysial hormone. Produced by the hypothalamus and stored and secreted by the posterior pituitary gland, oxytocin acts primarily as a neuromodulator in the brain.
Oxytocin plays an important role in the neuroanatomy of intimacy, specifically in sexual reproduction of both sexes, in particular during and after childbirth; its name, meaning "swift childbirth", comes from Greek, oksys "swift" and , tokos "birth." It is released in large amounts after distension of the cervix and uterus during labor, facilitating birth, maternal bonding, and, after stimulation of the nipples, lactation. Both childbirth and milk ejection result from positive feedback mechanisms..
Injected oxytocin analogues are used for labor induction and to support labor in case of difficult parturition. It has largely replaced ergometrine as the principal agent to increase uterine tone in acute postpartum hemorrhage. Oxytocin is also used in veterinary medicine to facilitate birth and to stimulate milk release. The tocolyticagent atosiban (Tractocile) acts as an antagonist of oxytocin receptors; this drug is registered in many countries to suppress premature labor between 24 and 33 weeks of gestation. It has fewer side effects than drugs previously used for this purpose (ritodrine, salbutamol, and terbutaline).
Usage and dosage:
Odinopoeia or oxytocin intravenous drip, once the 2.5 - 5 units, with Sodium Chloride Injection diluted to each 1ml contains 0.01 units. Intravenous drip of the beginning of every minute of not more than 0.001 to 0.002 units, each 15 - 30 minutes increased 0.001 to 0.002 units, to achieve the contractions and normal childbirth is similar, the fastest per minute of not more than 0.02 units, usually 0.002 to 0.005 units per minute.
Control postpartum hemorrhage per minute intravenous drip of 0.02 - 0.04 units, expulsion of the placenta after intramuscular injection of 5 to 10 units.
Lactogenic just before a 2 - 3 minutes, with nasal drops a 3 drop, drop into one side or both sides of the nostril.
Preparation and specification : oxytocin injection (1) 0.5ml:2.5 units (2) 1ml:5 (3) 1ml units 10 units;
Oxytocin nasal drops 1ml:40 units. The induction of labor or prenatal uterine atony: in 2.5-5 units in 500ml 5% glucose for intravenous drip slowly (10-30 drops / minute), maximum time 20 units. (2). Prevention of postpartum hemorrhage: intramuscular injection of 5-10 on each unit, or 5% glucose solution for intravenous drip.
The main contraindication, heart disease, a caesarean history and more than three fetal maternal disable.
The COA of Oxytocin:
|Certificate of Analysis for Oxytocin EP7 standard :|
Name of P
|Batch No:||120202||Analyzed on:||2012-2-29|
|Date of Manufacture:||2012-2-20||Quantity:||30g|
|CAS No.:||[50-56-6]||Expiry Date:||2014-2-19|
|1. Characteristic||White or almost white powder.||White powder|
Retention time conforms to that of the reference standard
|B. Amino acids||
Asp: 0.90-1.10;Glu: 0.90-1.10
Pro: 0.90-1.10;Gly: 0.90-1.10
Leu: 0.90-1.10;Tyr: 0.7-1.05
Half-Cys: 1.4-2.1;Ile: 0.90-1.10
|4. Related substances (HPLC)||Impurity A≤1.5%||0.15%|
|Impurity C≤1.5%||Not Detected|
|Other single impurity≤0.5%||0.13%|
|5. Acetic acid (HPLC)||6.0%-10.0%||7.1%|
|6. Water(KF)||NMT 5.0%||1.4%|
|7. Bacterial endotoxins||Less than 300 IU/mg||Conforms|
|8. AcN(GC)||Not more than 0.041%||Conforms|
|9. MeOH(GC)||Not more than 0.3%||Conforms|
|10. Triethylamine(GC)||Not more than 0.032%||Conforms|
Calculated with reference to anhydrous, acetic acid free substance
|on powder||NLT 80.0 %||90.4%|
|NLT 480 IU/mg||542IU/mg|
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