Hydrafinil (or 9-Fluorenol) is often a wakefulness-promoting agent, countering sleepiness and inattention. It is really an analogue and pro-drug of modafinil (also referred to as Provigil) - an ingredient used by Airforce pilots on long missions to remain awake and alert.
Hydrafinil (aka 9-Fluorenol) is a novel eugeroic nootropic that is certainly very similar in action to Modafinil. It was originally developed being a research compound to market wakefulness and alertness. Due to its reported efficacy as a eugeroic agent, it is becoming popular among advanced nootropics users. Interestingly, users report less stimulating effects than Modafinil, but a better ability to promote vigilance. Other reported benefits include attentional enhancement, increased motivation, subtle mood boost, improved cognitive function and ability to learn.
Hydrafinil, also known by its formal name 9-Fluorenol, is a eugeroic drug. state that it is more effective at keeping the target of the drug awake. In fact, an animal study conducted by Cephalon reported a 39% increase in effectiveness at keeping the mice awake over a 4 hour period. In addition, Hydrafinil is a weaker dopamine reuptake inhibitor .
Hydrafini, Fluorenol is an alcohol derivative of fluorene. In the most significant isomer, fluoren-9-ol or 9-hydroxyfluorene, the hydroxy group is located on the bridging carbon between the two benzene rings. Hydroxyfluorene can be converted to fluorenone by oxidation. It is a white-cream colored solid at room temperature.
Application Of Hydrafinil
Huperzine A has been investigated as a possible treatment for diseases characterized by neurodegeneration, particularly Alzheimer's disease. Huperzine A is also marketed as a dietary supplement with claims made for its ability to improve memory and mental function. Huperzine A has also been postulated as a potential treatment for myasthenia gravis.
Huperzine A is a cognitive enhancer that inhibits an enzyme that degrades the learning neurotransmitter, acetylcholine; due to this, a relative increase occurs. It belongs to the cholinergics class of molecules, and may be useful in fighting cognitive decline in the elderly. May need to be cycled.
Fluorenol is an alcohol derivative of fluorene. In the most significant isomer, fluoren-9-ol or 9-hydroxyfluorene, the hydroxy group is located on the bridging carbon between the two benzene rings. Hydroxyfluorene can be converted to fluorenone by oxidation. It is a white-cream colored solid at room temperature.
Dopamine reuptake inhibitor: An increase in dopamine production is known to improve cognition. Hydrafinil plays a role as a dopamine reuptake inhibitor, increasing dopamine concentrations.
5-HT6 antagonist: Antagonism of 5-HT6 receptor can result to increase in norepinephrine and dopamine concentrations in the Prefrontal cortex, as well as increasing the production of choline and glutamate in different parts of the brain. Makers of Hydrafinil theorize that it functions as a 5-HT6 receptor antagonist.
Increase Glutamate levels: As mentioned earlier, antagonism of 5-HT6 receptors increases the production of glutamate in the brain. This could lead to enhanced memory and learning process. There is a great possibility that Hydrafinil's function as a 5-HT6 receptor antagonist could result in the improvement of cognitive performance.
Increase Norepinephrine levels: Manufacturers of Hydrafinil claim that it increases norepinephrine levels specifically in the prefrontal cortex by antagonizing 5-HT6 receptor. Increase in concentrations of norepinephrine could result to improvement of cognition. However, there's no enough evidence to prove this theory.
Increase Histamine levels: Hydrafinil is known to enhance histamine levels in the hypothalamus. Histamine plays an important role in normalizing our circadian rhythm and regulating sleep-wake cycles.