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CAS 120014 06 4 donepezil hydrochloride For Alzheimer′S Disease Treatment

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CAS 120014 06 4 donepezil hydrochloride For Alzheimer′S Disease Treatment

CAS 120014 06 4 donepezil hydrochloride For Alzheimer′S Disease Treatment
CAS 120014 06 4 donepezil hydrochloride For Alzheimer′S Disease Treatment CAS 120014 06 4 donepezil hydrochloride For Alzheimer′S Disease Treatment

Large Image :  CAS 120014 06 4 donepezil hydrochloride For Alzheimer′S Disease Treatment

Product Details:

Brand Name: RedBird

Payment & Shipping Terms:

Minimum Order Quantity: 100Grams
Price: Negotiated
Packaging Details: Foil Bag
Delivery Time: 3-7days after received payment
Payment Terms: T/T, Western Union, MoneyGram
Supply Ability: 5000Kg Per Month
Detailed Product Description
Product Name: Donepezil Cas: 120014-06-4
Purity: 99% Appearance: White Powder
Grade: Pharmaceutical Grade Usage: Alzheimer′S Disease Treatment
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CAS 120014 06 4 donepezil hydrochloride For Alzheimer′S Disease Treatment

 

 

Product Name:DONEPEZIL HYDROCHLORIDE

Synonyms:AKOS 226-31;E-2020;DONEPEZIL HCL;ARICEPT;DonepezilHcl120011-70-3/;DONEPEZIL (DONEPEZIL HYDROCHLORIDE);2-[(1-Benzyl-4-piperidyl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one hydrochloride;Donepezil hydrochloride

CAS:110119-84-1

MF:C24H30ClNO3

MW:415.95

 

Description

 

Donepezil is a centrally acting reversible acetylcholinesterase inhibitor. Its main therapeutic use is in the palliative treatment of Alzheimer's disease. Common side effects include gastrointestinal upset. It has an oral bioavailability of 100% and easily crosses the blood-brain barrier. Because it has a biological half-life of about 70 hours, it can be taken once a day.

Donepezil has been tested in other cognitive disorders (and is sometimes used off label) including Lewy body dementia and vascular dementia, but it is not currently approved for these indications. Donepezil has been found to improve sleep apnea in Alzheimer's patients. Donepezil has also been studied in patients with Mild Cognitive Impairment, schizophrenia, attention deficit disorder, post-coronary bypass cognitive impairment, cognitive impairment associated with multiple sclerosis, CADASIL, and Down syndrome.

A 3 year NIH trial in patients with mild cognitive impairment reported that donepezil was superior to placebo in delaying rate of progression to dementia during the initial 18 months of the study but this was not sustained at 36 months. In a secondary analysis, a subgroup of individuals with the Apolipoprotein E4 genotype showed sustained benefits with donepezil throughout the study. However at this time donepezil is not indicated for prevention of dementia. Recent studies suggest that Donepezil can improve speech in children with autism. The studies found that speech of autistic children who were mild to moderately affected appeared to improve from the use of Donepezil.

CAS 120014 06 4 donepezil hydrochloride For Alzheimer′S Disease Treatment 0

 

Usage

Usage A nootropic. An inhibitor of acetylcholinesterase
Usage A labelled nootropic. An inhibitor of acetylcholinesterase.
Usage Antialzheimer
Usage Labeled Donepezil, intended for use as an internal standard for the quantification of Donepezilby GC- or LC-mass spectrometry.
Definition ChEBI: Donepezil hydrochloride is a centrally acting reversible acetyl cholinesterase inhibitor. Its main therapeutic use is in the treatment of Alzheimer's
disease where it is used to increase cortical acetylcholine.

 

Application

 


1. Donepezil binds and inactivates reversibly the cholinesterases, thus inhibiting hydrolysis of acetylcholine. This results in an increased acetylcholine concentrations at cholinergic synapses.

2. The precise mechanism of action of donepezil in patients with Alzheimer's disease is not fully understood. Certainly Alzheimer's disease involves a substantial loss of the elements of the cholinergic system and it is generally accepted that the symptoms of Alzheimer's disease are related to this cholinergic deficit, particularly in the cerebral cortex and other areas of the brain.

3. It is noted that the hippocampal formation plays an important role in the processes of control of attention, memory and learning. Just the severity of the loss of cholinergic neurons of the central nervous system (CNS) has been found to correlate with the severity of cognitive impairment.

 


COA

 

TEST ITEM SPECIFICATION RESULT
Appearance Off white to white crystalline powder Complies
Solubility freely Freely soluble in chloroform, soluble
in water and Acetic acid, slightly soluble in
Acetonitrile and ethanol, insoluble in
Ethylacetoacetate and n-hexane
Complies
Identification (1)By IR absorption ,To match with working
standard
Complies
(2) The retention time of the major peak of
the sample should accord with that of the
working standard.
Complies
(3) Test for chlorides. Reponds to the test
for Chlorides.
Complies
PH 4.0-7.0 6.10
Residue on ignition ≤0.1% 0.03%
Related substance Any Unkonwn single impurity≤0.3%
Total ≤0.5%
0.04%
0.18%
Heavy metal ≤10ppm <10ppm
Residual Solvents Methanol≤0.3%
Ethanol≤0.5%
Ethyl acetate≤0.5%
Toluene≤0.089%
Acetic acid≤0.5%
Not detected
Not detected
Not detected
Not detected
Not detected
Loss on drying ≤0.5% 0.20%
Assay On dried base, C24H29NO3·HCl
should be 98.0% to 102.0%
100.20%
Conclusion: The product complies to Enterprise standard

 

CAS 120014 06 4 donepezil hydrochloride For Alzheimer′S Disease Treatment 1

Abstract

 

Donepezil is a centrally acting reversible acetylcholinesterase inhibitor. Its main therapeutic use is in the palliative treatment of Alzheimer's disease. Common side effects include gastrointestinal upset. It has an oral bioavailability of 100% and easily crosses the blood-brain barrier. Because it has a biological half-life of about 70 hours, it can be taken once a day.

Donepezil has been tested in other cognitive disorders (and is sometimes used off label) including Lewy body dementia and vascular dementia, but it is not currently approved for these indications. Donepezil has been found to improve sleep apnea in Alzheimer's patients. Donepezil has also been studied in patients with Mild Cognitive Impairment, schizophrenia, attention deficit disorder, post-coronary bypass cognitive impairment, cognitive impairment associated with multiple sclerosis, CADASIL, and Down syndrome.

A 3 year NIH trial in patients with mild cognitive impairment reported that donepezil was superior to placebo in delaying rate of progression to dementia during the initial 18 months of the study but this was not sustained at 36 months. In a secondary analysis, a subgroup of individuals with the Apolipoprotein E4 genotype showed sustained benefits with donepezil throughout the study. However at this time donepezil is not indicated for prevention of dementia. Recent studies suggest that Donepezil can improve speech in children with autism. The studies found that speech of autistic children who were mild to moderately affected appeared to improve from the use of Donepezil.

 

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