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27262 48 2 Anesthesia Materials Levobupivacaine Hydrochloride Levobupivacaine HCl

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27262 48 2 Anesthesia Materials Levobupivacaine Hydrochloride Levobupivacaine HCl

27262 48 2 Anesthesia Materials Levobupivacaine Hydrochloride Levobupivacaine HCl
27262 48 2 Anesthesia Materials Levobupivacaine Hydrochloride Levobupivacaine HCl

Large Image :  27262 48 2 Anesthesia Materials Levobupivacaine Hydrochloride Levobupivacaine HCl

Product Details:

Brand Name: RedBird

Payment & Shipping Terms:

Minimum Order Quantity: 10Grams
Price: Negotiated
Packaging Details: Foil Bag
Delivery Time: 3-7days after received payment
Payment Terms: T/T, Western Union, MoneyGram
Supply Ability: 5000Kg Per Month
Detailed Product Description
Product Name: Levobupivacaine Hydrochloride Synonyms: Levobupivacaine HCl
Cas: 27262-48-2 Appearance: White Powder
Usage: Local Anesthetic Drugs Purity: 99%
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27262 48 2 Anesthesia Materials Levobupivacaine Hydrochloride Levobupivacaine HCl

 

Basic information

Product name: Levobupivacaine hydrochloride,Levobupivacaine Hcl
Synonyms: (S)-(-)-Bupivacaine Hydrochloride
No.: 27262-48-2
Packing: 25kg/drum
M.F.: C18H29ClN2O
M.W.: 324.8887
Appearance: White crystalline powde

 

Usage:

Levobupivacaine HCl is intended for single use and does not contain preservatives; any solution remaining from an open container should be discarded. For specific techniques and procedures, refer to standard contemporary textbooks. Levobupivacaine Compatibility and Admixtures: Levobupivacaine may not be compatible with alkaline solutions having a pH greater than 8.5. Studies have shown that levobupivacaine is compatible with 0.9% Sodium Chloride Injection USP and with saline solutions containing morphine, fentanyl and clonidine. Compatibility studies with other parenteral products have not been studied. Dilution Stability: Levobupivacaine diluted to levobupivacaine 0.625 to 2.5 mg/mL in 0.9% sodium chloride injection is physically and chemically stable when stored in polyvinyl chloride (PVC) bags at ambient room temperature for up to 24 hours. Aseptic technique should be used to prepare the diluted products. Admixtures of levobupivacaine should be prepared for single patient use only and used within 24 hours of preparation. The unused portion of diluted levobupivacaine should be discarded after each use.

 

Dosage:

The doses in Table 3 are those considered to be necessary to produce a successful block and should be regarded as guidelines for use. Individual variations in onset and duration occur. Epidural doses of up to 375 mg have been administered incrementally to patients during a surgical procedure. The maximum dose in 24 hours for intraoperative block and postoperative pain management is 695 mg. The maximum dose administered as a postoperative epidural infusion over 24 hours is 570 mg. The maximum dose administered to patients as a single fractionated injection is 300 mg for brachial plexus block. For cesarean section, the maximum recommended dose is 150 mg. Children: The maximum recommended dose for infiltration analgesia (ilioinguinal-iliohypogastric block) is 1.25 mg/kg/side.

27262 48 2 Anesthesia Materials Levobupivacaine Hydrochloride Levobupivacaine HCl 0

 

Description:

Levobupivacaine (rINN) is a local anaesthetic drug belonging to the amino amide group. It is the S-enantiomer of bupivacaine.


The hydrochloride salt of levobupivacaine, an amide derivative with anesthetic property. Levobupivacaine reversibly binds voltage-gated sodium channels to modulate ionic flux and prevent the initiation and transmission of nerve impulses (stabilizing neuronal membrane), thereby resulting in analgesia and anesthesia. In comparison with racemic bupivacaine, levobupivacaine is associated with less vasodilation and has a longer duration of action.

Levobupivacaine is an amide-type local anaesthetic. Levobupivacaine acts via blockade of voltage-sensitive ion channels in neuronal membranes, preventing transmission of nerve impulses. Localised and reversible anaesthesia is produced by interference with the opening of the sodium channel, which inhibits conduction of the action potential in nerves involved in sensory and motor activity and sympathetic activity. [1] Levobupivacaine displaces 3H-BTX from sodium channels of rat brain synaptosomes with IC50 of 2.9 μM and Hill coefficients of 1.2. When cell membrane is held at -80 mV, -70 mV, -60 mV or -100 mV, Levobupivacaine shows tonic inhibition of sodium channel in GH3 cells with IC50s of 132.1, 37.6, 21.6 and 264 μM, respectively. [2] Levobupivacaine depresses action potential of isolated axon in vitro.

 

Levobupivacaine (1mM) depresses action potential amplitude and maximal rate of rise of action potential (dV/dtmax) in the crayfish giant axons with value of 88 and 81 respectively, after perfusion for 15 min. [3] Levobupivacaine also displays activity on cardiac ion channels. In isolated ventricular myocytes, the apparent affinity for inactivated state of the sodium channel is 4.8 μM for Levobupivacaine, with a calculated KD of 39μM. On inhibition of cardiac delayed rectifier potassium channels (hKv1.5), the steady-state block for Levobupivacaine (20 μM) is 31%, with a calculated KD of 27.3 μM. Levobupivacaine may also inhibit cardiac calcium channels. 10 μM Levobupivacaine produces a 50% decrease in contractile force of guinea-pig papillary muscles.

 


Levobupivacaine is a local anaesthetic drug belonging to the amino amide group. It is the S-enantiomer of bupivacaine,it is a reversible neuronal sodium channel inhibitor, used as a long-acting local anesthetic.

Levobupivacaine hydrochloride is commonly marketed by Abbott under the trade name Chirocaine.

Compared to bupivacaine, levobupivacaine is associated with less vasodilation and has a longer duration of action. It is approximately 13 percent less potent (by molarity) than racemic bupivacaine and has a longer motor block onset time.

Levobupivacaine is an amide-type local anaesthetic. Levobupivacaine acts via blockade of voltage-sensitive ion channels in neuronal membranes, preventing transmission of nerve impulses. Localised and reversible anaesthesia is produced by interference with the opening of the sodium channel, which inhibits conduction of the action potential in nerves involved in sensory and motor activity and sympathetic activity. Levobupivacaine displaces 3H-BTX from sodium channels of rat brain synaptosomes with IC50 of 2.9 μM and Hill coefficients of 1.2. When cell membrane is held at -80 mV, -70 mV, -60 mV or -100 mV, Levobupivacaine shows tonic inhibition of sodium channel in GH3 cells with IC50s of 132.1, 37.6, 21.6 and 264 μM, respectively.

Levobupivacaine depresses action potential of isolated axon in vitro. Levobupivacaine (1mM) depresses action potential amplitude and maximal rate of rise of action potential (dV/dtmax) in the crayfish giant axons with value of 88 and 81 respectively, after perfusion for 15 min. [3] Levobupivacaine also displays activity on cardiac ion channels. In isolated ventricular myocytes, the apparent affinity for inactivated state of the sodium channel is 4.8 μM for Levobupivacaine, with a calculated KD of 39μM. On inhibition of cardiac delayed rectifier potassium channels (hKv1.5), the steady-state block for Levobupivacaine (20 μM) is 31%, with a calculated KD of 27.3 μM. Levobupivacaine may also inhibit cardiac calcium channels. 10 μM Levobupivacaine produces a 50% decrease in contractile force of guinea-pig papillary muscles.

Levobupivacaine has similar nerve blocking potency with bupivacaine. Levobupivacaine at a dose of 0.125%, inhibits motor and nocifensive pinch responses with maximum %MPE of 99 and 68 respectively, and inhibits the duration of deficits of motor and nocifensive pinch responses (60 and 30 , respectively) after sciatic nerve block.

27262 48 2 Anesthesia Materials Levobupivacaine Hydrochloride Levobupivacaine HCl 1

 

Product list
Product Name Number
Bupivacaine hydrochloride 14252-80-3
Bupivacaine 2180-92-9
Dibucaine hydrochloride 61-12-1
Ropivacaine hydrochloride 132112-35-7
Levobupivacaine hydrochloride 27262-48-2
Articaine hydrochloride 23964-57-0
Linocaine hydrochloride 6108-05-0
Benzocaine 94-09-7
Benzocaine hydrochloride 23239-88-5
Procaine hydrochloride 51-05-8
PROCAINE 59-46-1
Proparacaine hydrochloride 5875-06-9
Propitocaine hydrochloride 1786-81-8
Xylocaine 137-58-6
Tetracaine 94-24-6
Tetracaine hydrochloride 136-47-0
Dibucaine hydrochloride 61-12-1
Prilocaine 721-50-6
Procaine penicillin G 54-35-3
Sodium 2-Hydroxybutyrate 5094-24-6
Tetracaine hydrochloride 136-47-0
Pramoxine hydrochloride 637-58-1

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